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This is not a medical site. Information on this page is provided on a "best efforts" basis for interest only and does not constitute personal advice.
It is essential that you discuss medical matters with your doctor.

Glucosamine 500mg and Chondroitin 400mg

Taking Glucosamine and Chondroitin Sulfate together have been shown to increase their individual effects. But if you decide to take either or both, experts recommend taking the amount that has been used in studies. For Glucosamine sulphate, this amount is 1500 mg per day, for Chondroitin the amount is 1200mg per day

Chondroitin Sulfate exists naturally in your cartilage. It's thought to draw fluid into the tissue to give our cartilage more elasticity and to slow cartilage breakdown by protecting it from destructive enzymes. As a supplement, it is often taken along with Glucosamine to relieve Osteoarthritis symptoms. The combined use is to produce a "synergistic" effect in the drug. It's been prescribed for pain relief in Osteoarthritis in Europe for ages.

Although Chondroitin alone hasn't been proven to reverse cartilage loss, in some studies it appeared to help stop joint degeneration, improve function, and ease pain. In one placebo-controlled study, joint narrowing in the knee became stabilized in patients who were put on Chondroitin (Uebelhart) supplement. Another controlled study looked at Osteoarthritis of the finger joints for a period of three years. Among the group that took Chondroitin, there was a significant decrease in the number of patients with new erosions in their finger joints (Verbruggen).

Chondroitin in fact is a glycosaminoglycan that is concentrated in joint cartilage. Like Glucosamine, Chondroitin helps produce substances needed for the formation of connective tissue. In addition Chondroitin (unlike Glucosamine) also has the ability to protect existing cartilage from prematurely breaking down by inhibiting cartilage-destroying enzymes.

Chondroitin sulfates provide the structural components of joint cartilage, inhibit free radical enzymes that degrade joint cartilage and collagen, and facilitate the entry of Glucosamine into inflamed joints. Like Glucosamine, Chondroitin Sulfate attracts water into the cartilage matrix and stimulates the production of cartilage. It also has the ability to prevent enzymes from dissolving cartilage. Recent studies have shown extremely good results from long-term treatment with Chondroitin Sulfate (alone and in combination with Glucosamine) in reducing pain and increasing range of motion. Both glucosamine and chondroitin used together, however, will produce the best results.

Using Glucosamine and Chondroitin in combination may be synergistic. Recently, more and more clinical trials have begun to support the benefits of Glucosamine and Chondroitin for Osteoarthritis and overall joint health and resilience. One recent study appearing in the British Journal of Sports Medicine (February 2003) found that general mobility improved over time in both a placebo group and the experimental group being treated with Glucosamine. The results began to manifest after about four to eight weeks of treatment. The most significant benefits, according to the study, were in reducing the amount of perceived pain.
Meanwhile, the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), along with the National Center for Complementary and Alternative Medicine (NCCAM), launched a major clinical trial to study the effect of Glucosamine and Chondroitin Sulfate compounds in patients of Osteoarthritis. Both the agencies appear to believe that Glucosamine and Chondroitin Sulfate are "effective treatments that are key to improving the quality of life of Americans affected by Osteoarthritis." The results of this multi-center glucosamine study will be available in 2005.

Our Glucosamine 500mg and Chondroitin 400mg tablets are formulated to provide the suggested daily doses in three tablets, 1500mg of Glucosamine sulphate and 1200mg of Chondroitin.

Alternative Medicines use only marine Chondroitin, sourced exclusively from fish. We will not use 'Bovine' Chondroitin, sourced from the trachea of cattle, whilst its potential links to BSE cannot be ruled out.

Contra-indications/Precautions

If you are taking Chondroitin Sulfate in addition to a blood-thinning medication or daily aspirin therapy, have your blood clotting time checked more often. This supplement is similar in structure to the blood-thinning drug heparin, and the combination may cause bleeding in some people.

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